| S.N. | Bone | Cartilage |
| 1. | Matrix is composed of a tough, inflexible material, the ossein. | Matrix is composed of a firm, but flexible material, the chondrin. |
| 2. | Matrix is always impregnated with calcium salts. | Matrix may be free of or impregnated with calcium salts. |
| 3. | Bone cells lie in lacunae singly. | Cartilage cells lie in lacunae singly or in groups of two or four. |
| 4. | Osteocytes are irregular and give off branching processes in the developing bone. | Chondroblasts are oval and devoid of processes. |
| 5. | Lacunae give off canaliculi. | Lacunae lack canaliculi. |
| 6. | There are outer and inner layers of special bone forming cells, the osteoblasts, that produce new osteocytes, which secrete new lamellae for matrix. | There are no special cartilage forming cells. Cartilage grows by division of all chondroblasts. |
| 7. | Matrix occurs largely in concentric lamellae. | Matrix occurs in a homogenous mass. |
| 8. | Bone is highly vascular. | Cartilage is non vascular. |
| 9. | Bone may have a bone marrow in the medullary cavity. | Cartilage doesn’t have any such tissue called marrow. |
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