|Host itself produces antibodies to provide immunity.
|The antibodies produced in other hosts in passively received by the host.
|The immune system of the host actively participates.
|The host’s immune system doesn’t participate.
|It is induced by natural infection or vaccination (after contact with immunogen).
|It is conferred by the injection or introduction of preformed or readymade antibody in the host.
|Immune response is durable and more effective.
|Immune response is short lived and less effective.
|Immunity develops only after the lag period.
|Lag period is absent and hence immunity becomes effective immediately.
|It is used for prophylaxis to develop or induce resistance against microorganisms (antigens).
|It is applied for the treatment of certain disease like rabies and acute infections.
|It is not applicable for immune-deficient hosts.
|It is useful in immune-deficient host that cannot produce antibody by itself.
|Immunological memory is present due to presence of memory cells.
|There is no immunological memory.
|Subsequent challenge with the booster dose is more effective in immunity development.
|Subsequent administration of antibody is less effective due to ‘immune elimination’.
|After antigenic stimulus, negative phase may occur due to antigen combining with any pre-existing antibody in blood.
|There is no negative phase.